| DATE | TIME | ||
| Tue - 4/6 | 5:30 | @ Indians | Astros(4) - Indians(10) |
| Sat - 4/11 | 12:00 | @ Phillies | Astros(7) - Phillies(4) |
| Thu - 4/15 | 5:30 | @ Cardinals | Astros(5) - Cardinals(2) |
| Sat - 4/17 | 2:30 | Blue Jays | Blue Jays(0) - Astros(10) |
| Mon - 4/19 | 5:30 | Red Sox | Red Sox(7) - Astros(0) |
| Sun - 4/25 | 1:30 | Pirates | Pirates(11) - Astros(5) |
| Tue - 4/27 | 5:30 | @ Tigers | Astros(7) - Tigers(3) |
| Wed - 5/5 | 5:30 | @ Red Sox | Astros(2) - Red Sox(5) |
| Fri - 5/7 | 6:30 | Indians | Indians(11) - Astros(6) |
| Sat - 5/8 | 4:00 | Cardinals | Cardinals(4) - Astros(14) |
| Mon - 5/10 | 5:30 | @ Blue Jays | Astros(13) - Blue Jays(6) |
| Sat - 5/15 | 4:00 | @ Pirates | Astros(4) - Pirates(8) |
| Mon - 5/17 | 4:30 | Phillies | Phillies(4) - Astros(12) |
| Wed - 5/19 | 6:30 | Tigers | Tigers(6) - Astros(13) |
| Sat - 5/22 | 12:00 | @ Indians | Astros(9) - Indians(1) |
| Thu - 5/27 | 5:30 | @ Phillies | Astros(11) - Phillies(9) |
| Sat - 5/29 | 12:00 | @ Cardinals | Astros(11) - Cardinals(7) |
| Wed - 6/2 | 4:30 | Blue Jays | Blue Jays(12) - Astros(7) |
| Sat - 6/5 | 12:00 | Red Sox | Red Sox(12) - Astros(1) |
| Tue - 6/8 | 5:30 | Pirates | Pirates(4) - Astros(1) |
| Sat - 6/12 | 2:00 | @ Tigers | Astros(5) - Tigers(6) |