| DATE | TIME | ||
| Mon - 4/5 | 5:30 | Red Sox | Red Sox(7) - Cardinals(5) |
| Sat - 4/11 | 10:00 | @ Indians | Cardinals(8) - Indians(2) |
| Thu - 4/15 | 5:30 | Astros | Astros(5) - Cardinals(2) |
| Sat - 4/17 | 9:00 | @ Phillies | Cardinals(13) - Phillies(1) |
| Wed - 4/21 | 5:30 | @ Blue Jays | Cardinals(11) - Blue Jays(6) |
| Sat - 4/24 | 10:00 | Tigers | Tigers(2) - Cardinals(3) |
| Mon - 4/26 | 5:30 | Pirates | Pirates(8) - Cardinals(7) |
| Mon - 5/3 | 5:30 | Indians | Indians(15) - Cardinals(11) |
| Fri - 5/7 | 4:30 | @ Red Sox | Cardinals(1) - Red Sox(5) |
| Sat - 5/8 | 4:00 | @ Astros | Cardinals(4) - Astros(14) |
| Tue - 5/11 | 5:30 | Phillies | Phillies(10) - Cardinals(1) |
| Sat - 5/15 | 2:00 | @ Tigers | Cardinals(6) - Tigers(7) |
| Tue - 5/18 | 4:30 | Blue Jays | Blue Jays(2) - Cardinals(3) |
| Thu - 5/20 | 6:30 | @ Pirates | Cardinals(4) - Pirates(15) |
| Sat - 5/22 | 4:00 | Red Sox | Red Sox(16) - Cardinals(11) |
| Wed - 5/26 | 5:30 | @ Indians | Cardinals(1) - Indians(11) |
| Sat - 5/29 | 12:00 | Astros | Astros(11) - Cardinals(7) |
| Tue - 6/1 | 6:30 | @ Phillies | Cardinals(8) - Phillies(10) |
| Sat - 6/5 | 2:00 | @ Blue Jays | Cardinals(6) - Blue Jays(10) |
| Thu - 6/10 | 5:30 | Tigers | Tigers(3) - Cardinals(9) |
| Sat - 6/12 | 10:00 | Pirates | Pirates(3) - Cardinals(9) |