| DATE | TIME | ||
| Thu - 4/8 | 5:30 | Blue Jays | Blue Jays(6) - Pirates(2) |
| Sat - 4/11 | 4:00 | @ Red Sox | Pirates(11) - Red Sox(12) |
| Tue - 4/13 | 5:30 | Tigers | Tigers(1) - Pirates(6) |
| Sat - 4/17 | 4:30 | @ Indians | Pirates(14) - Indians(1) |
| Tue - 4/20 | 5:30 | Phillies | Phillies(5) - Pirates(12) |
| Sun - 4/25 | 1:30 | @ Astros | Pirates(11) - Astros(5) |
| Mon - 4/26 | 5:30 | @ Cardinals | Pirates(8) - Cardinals(7) |
| Thu - 5/6 | 5:30 | @ Phillies | Pirates(15) - Phillies(6) |
| Sat - 5/8 | 2:00 | @ Tigers | Pirates(22) - Tigers(1) |
| Wed - 5/12 | 5:30 | Indians | Indians(9) - Pirates(12) |
| Fri - 5/14 | 4:30 | @ Blue Jays | Pirates(16) - Blue Jays(2) |
| Sat - 5/15 | 4:00 | Astros | Astros(4) - Pirates(8) |
| Tue - 5/18 | 6:30 | Red Sox | Red Sox(20) - Pirates(4) |
| Thu - 5/20 | 6:30 | Cardinals | Cardinals(4) - Pirates(15) |
| Sat - 5/22 | 2:00 | Blue Jays | Blue Jays(4) - Pirates(10) |
| Tue - 5/25 | 5:30 | @ Red Sox | Pirates(4) - Red Sox(14) |
| Sat - 5/29 | 2:00 | Tigers | Tigers(10) - Pirates(11) |
| Wed - 6/2 | 6:30 | @ Indians | Pirates(3) - Indians(1) |
| Sat - 6/5 | 10:00 | Phillies | Phillies(12) - Pirates(6) |
| Tue - 6/8 | 5:30 | @ Astros | Pirates(4) - Astros(1) |
| Sat - 6/12 | 10:00 | @ Cardinals | Pirates(3) - Cardinals(9) |